Kuzungulira kwa zomangira, Pali mabanja awiri a ma screw extruder, kusankha kwazinthu ndikofunikira pakupanga chinthu chopambana…
Kuzungulira kwa zomangira kumapanga kusakaniza kogawa ndi kufalikira.Kusakaniza kogawa kumakulitsa kugawanika ndi kukonzanso kwa zipangizozo pamene kuchepetsa kulowetsedwa kwa mphamvu mwa kusakaniza ndi zotsatira zochepa zowonjezera zowonjezera ndi planar-shear.Izi uniformly zikuphatikiza zipangizo koma sikuchepetsa kwambiri obalalika tinthu tinthu kukula ndipo amapereka zochepa matenthedwe ndi kukameta ubweya wa zipangizo tcheru.
Kusanganikirana kobalalika kumagwiritsa ntchito minda yometa ubweya yotalikirapo kuti iphwanyire zida zobalalitsidwa kukhala zazing'ono, pogwiritsa ntchito mphamvu kapena kupitilira pang'ono mulingo wofunikira kuti ziphwanye.
Kugwiritsa ntchito zinthu zosiyanasiyana kusanganikirana kumathandiza amapasa wononga extruder kuchita onse tinthu kukula kuchepetsa ndi kusanganikirana kuti APIs akhoza kuphatikizidwa mu polima mu omwazika mawonekedwe kapena, ngati API solubility mu polima ndi mkulu mokwanira, mu mawonekedwe kusungunuka.Popeza extrudate kuzirala mofulumira exiting extruder, API iliyonse kuti kusungunuka polima pa kutentha kusanganikirana sangathe recrystallize pa kuzirala, kumabweretsa supersaturated olimba njira.Zikatero kukhazikika kwa mankhwalawa kuyenera kutsatiridwa kwambiri monga kukonzanso kwa API pamiyeso yayitali ndikotheka, makamaka pakutentha kosungirako kosungirako komanso kutsitsa kwa API, ndipo kungakhudze moyo wa alumali wa chinthu chomaliza.
Pali mabanja awiri okhala ndi ma screw extruder: high-speed energy input (HSEI) ma twin-screw extruders, omwe amagwiritsidwa ntchito kwambiri pophatikiza, kukonza zowonongeka ndi / kapena devolatilization, ndi low-speed late fusion (LSLF) twin-screw extruders, idapangidwa kuti isakanize pakameta ubweya wochepa ndikupopera pazovuta zofananira.Zomangira zimatha kukhala mozungulira (kudzipukuta pawokha), kapena kuzungulira (kusiyana kwa kalendala), zotulutsa zambiri zomwe zimagwiritsidwa ntchito kusanganikirana zimakhala zozungulira.
Mitundu yosiyanasiyana yakufa imagwiritsidwa ntchito kuumba extrudate ku mbiri yomwe mukufuna.Zomwe zimafa zimaphatikizapo mapepala ndi mafilimu omwe amagwiritsidwa ntchito popanga mafilimu a transdermal, ma strand dies omwe amagwiritsidwa ntchito popanga machubu azachipatala ndi zida zina zotulutsa mankhwala, mawonekedwe amafa omwe amagwiritsidwa ntchito poumba, ndi co-extrusion dies omwe amagwiritsidwa ntchito popanga zida zosungira.Osiyana kunsi mtsinje wothandiza zigawo zikuluzikulu amagwiritsidwanso ntchito pomaliza, kuphatikizapo osambira madzi ndi mpweya mipeni kwa kuzirala, malamba conveyor kusuntha mankhwala extruded kuchokera kufa mpaka mapeto a mzere, strand-odula kudula extrudate mu chubu kapena ndodo, ndi spoolers zosonkhanitsira extrudate.Ma pelletizers amagwiritsidwa ntchito podula extrudate m'zidutswa zing'onozing'ono kuti mudzaze kapisozi mwachindunji komanso ngati zida zina zomangira jekeseni kuti apange chomaliza.
Monga momwe zilili ndi mtundu uliwonse wa mlingo, kusankha zinthu ndizofunikira kwambiri pakupanga mankhwala opambana.Pazinthu zambiri, polima iyenera kukhala ya thermoplastic, yokhazikika pa kutentha komwe kumagwiritsidwa ntchito, komanso yogwirizana ndi API panthawi ya extrusion.Pamitundu yolimba ya mulingo wapakamwa, ma polima osungunuka m'madzi nthawi zambiri amasankhidwa pakati pa ma polima omwe amagwiritsidwa ntchito kale muzamankhwala monga poly(ethylene glycol) ndi poly(vinylpyrrolidinone).Ndichidwi chowonjezereka chogwiritsa ntchito HME pazogulitsa zamankhwala, ogulitsa ma polima akuluakulu ayambanso kupereka ma polima opangidwa makamaka kuti azigwiritsidwa ntchito pazamankhwala.Pazida zopangira mankhwala, ma polima nthawi zambiri sasungunuke ndi madzi, ndipo zinthu zambiri zomwe zikupangidwa zimagwiritsa ntchito ethylene vinyl acetate copolymers (EVAs) kapena polyurethanes.
HME imalola API kuti isakanizidwe ndi polima pansi pa kumeta ubweya ndi kupsinjika kwa kutentha kotero kuti pakhale zochepetsera zochepa zokhudzana ndi ndondomeko ya API.Antioxidants nthawi zambiri amaphatikizidwa mkati mwa mapangidwe, ndipo nthawi yochepa yokhala mu mbiya (makamaka pa dongosolo la mphindi) imathandizanso kuchepetsa kuwonongeka kwa kutentha makamaka poyerekeza ndi kusakanikirana kwa batch ndi njira zina zowonjezera.
Njira imodzi yowongolerera ma kinetics a mankhwala kuchokera ku zida monga mphete zolowera m'mimba ndikuwonjezera njira yosavuta yotulutsa.Kutulutsa kwapakatikati kwa chingwe chapakati chodzaza ndi mankhwala chokhala ndi sheath yotulutsa polima yomwe imatsekereza pachimake munjira imodzi yolumikizirana imapanga chingwe chapakati-chingwe chamitundu iwiri.Mutu wopangidwa mwapadera umadyetsedwa ndi ma perpendicular extruder - imodzi ikupereka zomwe zili pachimake, inayo ikupereka zida za sheath.Chingwe chapakati-sheath chimadulidwa ndipo mapeto ake amalumikizidwa kuti apange chipangizo chomaliza.
HME imapereka opanga mankhwala a zipangizo zamankhwala, kusungunula mafomu a mlingo wa pakamwa ndi zipangizo zopangira mankhwala ndi njira yopangira njira yomwe imapangitsa kuti API isakanike ndi polima, ndikuchepetsa kuwonongeka kwa API, komanso imatsegula chitseko cha mankhwala omwe sangathe kukonzekera ndi njira zina.
Nthawi yotumiza: Aug-01-2017