Hot-melt extrusion (HME) ndi njira yokhazikitsidwa yomwe yakhala ikugwiritsidwa ntchito kuyambira koyambirira kwa zaka za m'ma 1930, makamaka popanga mapulasitiki ...
Pali mitundu iwiri ya extruders: single ndi amapasa wononga extruders.Single screw extruder makamaka amagwiritsidwa ntchito kusungunula ndi kutumiza ma polima kuti atulutse mawonekedwe osalekeza, pomwe ma screw extruder amapasa amagwiritsidwa ntchito kusakaniza ma polima okhala ndi zida zowonjezera (pigments, fillers, reinforcers, ndi APIs), komanso devolatilization.Popanga mankhwala opangira mankhwala, omwe amafunikira kusakanikirana kwamtundu umodzi komanso kosasinthasintha wa zosakaniza zingapo, amapasa amapasa wononga extruder chifukwa kasinthasintha wa zomangira inter-meshing amapereka bwino kusanganikirana kubala homogeneous olimba munali finely omwazika API particles, kapena njira yolimba ya API mu polima.Izi zitha kukonza kuchuluka kwa kusungunuka komanso kuthekera kwa bioavail kwa ma API osasungunuka bwino m'madzi.Uniformly distrib-uted API ndiyonso yofunika kwambiri popanga zida zopangira mankhwala okhala ndi intra- and inter-batch reproducibility of drug-release ki-netics.
Kusungunula kumatheka ndi kutentha kwa fric-tional mkati mwa mbiya, ndi ma twin-screw extruders, pamene zipangizo zimameta pakati pa zomangira zozungulira ndi pakati pa zomangira ndi khoma la mbiya pamene zimatumizidwa.Mgolowu umatenthedwanso ndi ma heaters okwera pa mbiya, kapena utakhazikika ndi madzi.Kutentha kwa gawo la mbiya nthawi zambiri kumakhala kokwanira kuti kusungunuka kwa kusungunuka kukhale kocheperako kuti kulole kutsitsa mbiya ndikusakanikirana koyenera, ndikusunga kutentha kocheperako kupewetsa kuwonongeka kwa zinthuzo.
The zomangira amapasa wononga extruder zambiri kupereka mitundu yosiyanasiyana ya kusanganikirana ndi kupereka zinthu pa madera osiyanasiyana mu mbiya.Pakupanga zinthu, zomangira zokhala ndi maelementi angapo zoyikidwa pa shaft wamba, zimalola kukonza ndi kukhathamiritsa kwa mapangidwe a screw pachinthu chilichonse.Magawo a wononga akhoza kupangidwa kuti achite kuchepetsa kukula kwa tinthu, kusakaniza ndi kutumiza ntchito.Utali wa wononga poyerekezera ndi mbiya awiri (chiŵerengero cha L/D) amasankhidwa kukhathamiritsa mlingo wa kusakaniza ndi chiwerengero cha madera zofunika kukwaniritsa chomaliza mankhwala char-acteristics.Chitsanzo cha zonse modular screw.Zomangira zachidutswa chimodzi zitha kumangidwa molingana ndi zomangira zachitukuko, koma ndizosavuta kuyeretsa kuti zitsatire cGMP.
Nthawi yotumiza: Jun-03-2017